Increased frontal functional networks in adult survivors of childhood brain tumorsReportar como inadecuado

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Journal Title:

NeuroImage: Clinical


Volume 11


Elsevier: Creative Commons | 2016-01-01, Pages 339-346

Type of Work:

Article | Final Publisher PDF

Abstract: Childhood brain tumors and associated treatment have been shown to affect brain development and cognitive outcomes. Understanding the functional connectivity of brain many years after diagnosis and treatment may inform the development of interventions to improve the long-term outcomes of adult survivors of childhood brain tumors. This work investigated the frontal region functional connectivity of 16 adult survivors of childhood cerebellar tumors after an average of 14.9 years from diagnosis and 16 demographically-matched controls using resting state functional MRI rs-fMRI. Independent component analysis ICA was applied to identify the resting state activity from rs-fMRI data and to select the specific regions associated with executive functions, followed by the secondary analysis of the functional networks connecting these regions. It was found that survivors exhibited differences in the functional connectivity in executive control network ECN, default mode network DMN and salience network SN compared to demographically-matched controls. More specifically, the number of functional connectivity observed in the survivors is higher than that in the controls, and with increased strength, or stronger correlation coefficient between paired seeds, in survivors compared to the controls. Observed hyperconnectivity in the selected frontal functional network thus is consistent with findings in patients with other neurological injuries and diseases.

Subjects: Health Sciences, Radiology - Environmental Sciences - Research Funding: This research was supported in part by a Research Scholar Grant from the American Cancer Society to TZK #RSGPB-CPPB-114044, a project grant from the National Natural Science Foundation of China to HC 81460273 and a research grant from National Cancer Institute to HM 5R01CA169937-01A1.

Keywords: Resting state fMRI - Functional connectivity - Brain tumor - Survivor -

Autor: Hongbo Chen, Liya Wang, Tricia King, Hui Mao,



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