Four-dimensional 4D Motion Detection to Correct Respiratory Effects in Treatment Response Assessment Using Molecular Imaging BiomarkersReportar como inadecuado




Four-dimensional 4D Motion Detection to Correct Respiratory Effects in Treatment Response Assessment Using Molecular Imaging Biomarkers - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal Title:

Technology in Cancer Research and Treatment

Volume:

Volume 13, Number 6

Publisher:

SAGE Publications UK and US: Open Access Titles | 2014-12-01, Pages 571-582

Type of Work:

Article | Final Publisher PDF

Abstract: Observing early metabolic changes in positron emission tomography PET is an essential tool to assess treatment efficiency in radiotherapy. However, for thoracic regions, the use of three-dimensional 3D PET imaging is unfeasible because the radiotracer activity is smeared by the respiratory motion and averaged during the imaging acquisition process. This motion-induced degradation is similar in magnitude with the treatment-induced changes, and the two occurrences become indiscernible. We present a customized temporal-spatial deformable registration method for quantifying respiratory motion in a four-dimensional 4D PET dataset. Once the motion is quantified, a motion-corrected MC dataset is created by tracking voxels to eliminate breathing-induced changes in the 4D imaging scan. The 4D voxel-tracking data is then summed to yield a 3D MC-PET scan containing only treatment-induced changes. This proof of concept is exemplified on both phantom and clinical data, where the proposed algorithm tracked the trajectories of individual points through the 4D datasets reducing motion to less than 4 mm in all phases. This correction approach using deformable registration can discern motion blurring from treatment-induced changes in treatment response assessment using PET imaging.

Keywords: Science and Technology - Life Sciences and Biomedicine - Oncology - ONCOLOGY - Positron emission tomography - Treatment response assessment - Thoracic motion - POSITRON-EMISSION-TOMOGRAPHY - BOUND-CONSTRAINED OPTIMIZATION - FREE-FORM DEFORMATIONS - NONRIGID REGISTRATION - DEFORMABLE REGISTRATION - PET IMAGES - MR-IMAGES - MODEL - RECONSTRUCTION - RADIOTHERAPY -



Autor: Walter Curran, Ian Crocker, Eduard Schreibmann, David Schuster, T Fox,

Fuente: https://open.library.emory.edu/



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