18F-FDG-PET-CT parameters as imaging biomarkers in oral cavity squamous cell carcinoma, is visual analysis of PET and contrast enhanced CT better than the numbersReportar como inadecuado




18F-FDG-PET-CT parameters as imaging biomarkers in oral cavity squamous cell carcinoma, is visual analysis of PET and contrast enhanced CT better than the numbers - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal Title:

European Journal of Radiology

Volume:

Volume 84, Number 6

Publisher:

Elsevier | 2015-06-01, Pages 1171-1176

Type of Work:

Article | Post-print: After Peer Review

Abstract: Purpose: This study was designed to seek associations between positron emission tomography-computed tomography PET-CT parameters, contrast enhanced neck computed tomography CECT and pathological findings, and to determine the potential prognostic value of PET-CT and CECT parameters in oral cavity squamous cell carcinoma OCSCC. Materials and method: 36 OCSCC patients underwent staging PET-CT and 30-36 of patients had CECT. PET-CT parameters were measured for the primary tumor and the hottest involved node, including maximum, mean, and peak standardized uptake values SUV max, SUV mean, and SUV peak, metabolic tumor volume MTV, total lesion glycolysis TLG, standardized added metabolic activity SAM, and normalized standardized added metabolic activity N SAM. Qualitative assessment of PET-CT and CECT were also performed. Pathological outcomes included: perineural invasion, lymphovascular invasion, nodal extracapsular spread, grade, pathologic T and N stages. Multivariable logistic regression models were fit for each parameter and outcome adjusting for potentially confounding variables. Multivariable Cox proportional hazards models were used for progression free survival PFS, locoregional recurrence free survival LRFS, overall survival OS and distant metastasis free survival DMFS. Results: In multivariable analysis, patients with high ≥ median tumor SUV max OR 6.3, SUV mean OR 6.3, MTV OR 19.0, TLG OR 19.0, SAM OR 11.7 and N SAM OR 19.0 had high pathological T-stage T3-T4 p < 0.05. Ring-heterogeneous pattern on CECT qualitative assessment was associated with worse DMFS and OS. Conclusion: High PET-CT parameters were associated with pathologically advanced T stage T3-T4. Qualitative assessment of CECT has prognostic value. PET-CT parameters did not predict clinical outcome.

Subjects: Health Sciences, Oncology - Health Sciences, Pathology - Health Sciences, Radiology - Research Funding: Research reported in this publication was supported in part by the Biostatistics and Bioinformatics Share Resource of Winship Cancer Institute of Emory University and NIH-NCI under award number P30CA138292.

Keywords: Life Sciences and Biomedicine - Radiology, Nuclear Medicine and Medical Imaging - Positron emission tomography - Computed tomography - Squamous cell carcinoma - Head and neck carcinoma - TOTAL LESION GLYCOLYSIS - METABOLIC TUMOR VOLUME - PROGNOSTIC VALUE - NECK-CANCER - SURVIVAL - HEAD - PITFALLS -



Autor: Ayse Karagulle Kendi, A. Tuba Kendi, Amanda Corey, Kelly Magliocca, Dana C. Nickleach, James Galt, Jeffrey Switchenko, Mark El-De

Fuente: https://open.library.emory.edu/



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