Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012Reportar como inadecuado

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Journal Title:



Volume 11, Number 6


Public Library of Science | 2016-06-13, Pages e0157301-e0157301

Type of Work:

Article | Final Publisher PDF

Abstract: Background: Worldwide, asthma is a leading cause of morbidity, mortality and economic burden, with significant gender and racial disparities. However, little attention has been given to the independent role of age on lifetime asthma severity and hospitalization. We aimed to assess the effect of age, gender, race and ethnicity on indicators of asthma severity including asthma related hospitalization, mortality, hospital cost, and the rate of respiratory failure. Methods: We analyzed the 2011 and 2012 Healthcare Cost and Utilization Project- National Inpatient Sample NIS. We validated and extended those results using the National Heart, Lung, and Blood Institute-Severe Asthma Research Program SARP; 2002-2011 database. Severe asthma was prospectively defined using the stringent American Thoracic Society ATS definition. Results: Hospitalization for asthma was reported in 372,685 encounters in 2012 and 368,528 in 2011. The yearly aggregate cost exceeded $2 billion. There were distinct bimodal distributions for hospitalization age, with an initial peak at 5 years and a second at 50 years. Likewise, this bimodal age distribution of patients with severe asthma was identified using SARP. Males comprised the majority of individuals in the first peak, but women in the second. Aggregate hospital cost mirrored the bimodal peak distribution. The probability of respiratory failure increased with age until the age of 60, after which it continued to increase in men, but not in women. Conclusions: Severe asthma is primarily a disease of young boys and middle age women. Greater understanding of the biology of lung aging and influence of sex hormones will allow us to plan for targeted interventions during these times in order to reduce the personal and societal burdens of asthma.

Subjects: Health Sciences, Epidemiology - Health Sciences, Health Care Management - Health Sciences, Medicine and Surgery - Research Funding: SCE received funding from the National Institute of Health-National Heart, Lung, and Blood Institute: HL109250, HL081064, HL69170, HL103453, U10 HL109250, and UL1TR000439.

Keywords: Science and Technology - Multidisciplinary Sciences - SECONDARY DATABASES - SIMULATED PATIENTS - NATIONAL HEART - EXACERBATIONS - PREVALENCE - CHILDHOOD - SYMPTOMS - Asthma - Respiratory failure - Hospitals - Death rates - Age distribution - Chronic obstructive pulmonary disease - Health care - Health economics -

Autor: Joe G. Zein, Belinda L. Udeh, W. Gerald Teague, Siran M. Koroukian, Nicholas K. Schlitz, Eugene R. Bleecker, William B. Busse, Wi



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