Resolving uncertainty in the spatial relationships between passive benzene exposure and risk of non-Hodgkin lymphomaReportar como inadecuado

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Journal Title:

Cancer Epidemiology


Volume 41


Elsevier | 2016-03-02, Pages 139-151

Type of Work:

Article | Final Publisher PDF

Abstract: Background: Benzene is a known occupational carcinogen associated with increased risk of hematologic cancers, but the relationships between quantity of passive benzene exposure through residential proximity to toxic release sites, duration of exposure, lag time from exposure to cancer development, and lymphoma risk remain unclear. Methods: We collected release data through the Environmental Protection Agency's Toxics Release Inventory TRI from 1989 to 2003, which included location of benzene release sites, years when release occurred, and amount of release. We also collected data on incident cases of non-Hodgkin lymphoma NHL from the Georgia Comprehensive Cancer Registry GCCR for the years 1999-2008. We constructed distance-decay surrogate exposure metrics and Poisson and negative binomial regression models of NHL incidence to quantify associations between passive exposure to benzene and NHL risk and examined the impact of amount, duration of exposure, and lag time on cancer development. Akaike's information criteria AIC were used to determine the scaling factors for benzene dispersion and exposure periods that best predicted NHL risk. Results: Using a range of scaling factors and exposure periods, we found that increased levels of passive benzene exposure were associated with higher risk of NHL. The best fitting model, with a scaling factor of 4 kilometers km and exposure period of 1989-1993, showed that higher exposure levels were associated with increased NHL risk Level 4 1.1-160 kilograms kg vs. Level 1: risk ratio 1.56 1.44-1.68, Level 5 >160 kg vs. Level 1: 1.60 1.48-1.74. Conclusions: Higher levels of passive benzene exposure are associated with increased NHL risk across various lag periods. Additional epidemiological studies are needed to refine these models and better quantify the expected total passive benzene exposure in areas surrounding release sites.

Subjects: Health Sciences, Oncology - Environmental Sciences - Health Sciences, Public Health - Research Funding: Research reported in this publication was supported in part by Dr. Switchenko’s Pam Rollins Research Award, a philanthropic award provided by the Winship Cancer Institute of Emory University, by Dr. Flowers’ National Cancer InstituteR21CA158686, and by the NIH-NCI under award number P30CA138292.

Keywords: Science and Technology - Life Sciences and Biomedicine - Oncology - Public, Environmental and Occupational Health - Spatial epidemiology - Lymphoma - Environmental epidemiology - Toxic release sites - EPA - B-CELL LYMPHOMA - INTERLYMPH-CONSORTIUM - POLYMORPHISMS - SUSCEPTIBILITY - METAANALYSIS - ASSOCIATION - PROXIMITY - SUBTYPES - WORKERS - COHORT -

Autor: Jeffrey Switchenko, Catherine Bulka, Kevin Ward, Jean Koff, A. Rana Bayakly, P Barry Ryan, Lance Waller, Christopher Flowers,



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