Baseline Ultrasound and Clinical Correlates in Children with Cystic FibrosisReport as inadecuate

Baseline Ultrasound and Clinical Correlates in Children with Cystic Fibrosis - Download this document for free, or read online. Document in PDF available to download.

Journal Title:

Journal of Pediatrics


Volume 167, Number 4


Elsevier | 2015-10-01, Pages 862-+

Type of Work:

Article | Post-print: After Peer Review

Abstract: Objective: To investigate the relationship between abdominal ultrasound US findings and demographic, historical and clinical features in children with CF.Study design: Children age 3-12 years with CF without known cirrhosis, were enrolled in a prospective, multi-center study of US to predict hepatic fibrosis. Consensus US patterns were assigned by 3 radiologists as normal, heterogeneous, homogeneous, or cirrhosis. Data were derived from direct collection and U.S. or Toronto CF registries. Chi-square or ANOVA were used to compare variables among US groups and between normal and abnormal. Logistic regression was used to study risk factors for having abnormal US.Results: Findings in 719 subjects were normal n=590, 82.1%, heterogeneous 64, 8.9%, homogeneous 41, 5.7%, and cirrhosis 24, 3.3%. Cirrhosis p=0.0004, homogeneous p<0.0001 and heterogeneous p=0.03 were older than normal. More males were heterogeneous p=0.001. More heterogeneous 15.0%, p=0.009 and cirrhosis 25.0%, p=0.005 had CF-related diabetes or impaired glucose tolerance versus normal 5.4%. Early infection with Pseudomonas aeruginosa <2 years old was associated with a lower risk OR 0.42, p=0.0007 of abnormal. Ursodeoxycholic acid use OR 3.69, p <0.0001 and CF-related diabetes OR 2.21, p=0.019 were associated with increased risk of abnormal.Conclusions: Unsuspected cirrhosis is seen in 3.3% of young patients with CF, heterogeneous in 8.9%. abnormal US is associated with CF-related diabetes, and early P aeruginosa is associated with normal US. Prospective assessment of these risk factors may identify potential interventional targets.

Subjects: Health Sciences, Medicine and Surgery - Health Sciences, Radiology - Research Funding: Supported by the Cystic Fibrosis Foundation NARKEW07A0 Colorado; DK062453 and DK62456 The University of Michigan, the National Institutes of Health NIH-National Center for Advancing Translational Sciences NCATS; UL1 TR001082 Colorado; UL1 TR000077 Cincinnati, DK084536-07; UL1 TR000150 Northwestern University, Clinical and Translational Science Institute CTSI UL1TR001108 Indiana University, Institute for Clinical and Translational Research-NCATS-NIH UL1 TR 001079 Johns Hopkins, NIH-NUCATS-Institute of Translational Health Sciences RR025014, and NIH Clinical and Translational Science Award TR000423 University of Washington.

Keywords: Science and Technology - Life Sciences and Biomedicine - Pediatrics - sonography - imaging - risk - hepatobiliary - CFTR dysfunction - FATTY LIVER-DISEASE -

Author: Daniel H. Leung, Wen Ye, Jean P. Molleston, Alexander Weymann, Simon Ling, Shruti M. Paranjape, Rene Romero, Sara Jane Schwarzenb



Related documents