Immunohistochemical expression of PAX5 and TdT by Merkel cell carcinoma and pulmonary small cell carcinoma: a potential diagnostic pitfall but useful discriminatory markerReportar como inadecuado




Immunohistochemical expression of PAX5 and TdT by Merkel cell carcinoma and pulmonary small cell carcinoma: a potential diagnostic pitfall but useful discriminatory marker - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal Title:

International Journal of Clinical and Experimental Pathology

Volume:

Volume 6, Number 2

Publisher:

e-Century Publishing | 2013-01-15, Pages 142-147

Type of Work:

Article | Final Publisher PDF

Abstract: Background: Merkel cell carcinoma is a high-grade neuroendocrine carcinoma of skin that is characterized by immature cells which, because of its striking morphologic similarity, may be confused with other small round blue cell tumors such as pulmonary small cell carcinoma or lymphoblastic leukemia-lymphoma. Immunohistochemistry is therefore paramount to ensuring accurate diagnostic distinction between these tumors. The aim of our study was to evaluate and compare the expression of PAX5 and Terminal deoxynucleotidyl transferase TdT, in Merkel cell carcinoma and pulmonary small cell carcinoma. Design: PAX5 and TdT immunohistochemical stains were performed on 27 Merkel cell carcinomas and 10 pulmonary small cell carcinomas. Results: PAX5 was expressed in 24-27 89% Merkel cell carcinomas and 0-10 0% pulmonary small cell carcinomas. TdT was expressed in 21-27 78% Merkel cell carcinomas and 9-10 90% pulmonary small cell carcinomas. Conclusions: Our study confirms that PAX5 and TdT expression can be expressed in a high percentage of Merkel cell carcinomas and so when positive are not diagnostic of lymphoblastic leukemia-lymphoma. When dealing with metastatic lesions, PAX5 negativity would favor a diagnosis of pulmonary small cell carcinoma over Merkel cell carcinoma. In addition, TTF-1 negative pulmonary small cell carcinoma is to be differentiated from Merkel cell carcinoma.

Subjects: Health Sciences, Pathology - Health Sciences, Immunology - Health Sciences, Oncology - Keywords: Science and Technology - Life Sciences and Biomedicine - Oncology - Pathology - ONCOLOGY - PATHOLOGY - Merkel cell carcinoma - PAX5 - TdT - small cell carcinoma - lung - TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE - PARAFFIN SECTIONS - MALIGNANT-LYMPHOMAS - CYTOKERATIN-20 - DISTINCTION - GENE - LUNG - SKIN -



Autor: Ravindra Kolhe, Michelle Reid, Jeffrey R Lee, Cynthia Cohen, Preetha Ramalingam,

Fuente: https://open.library.emory.edu/



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