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Journal Title:

Advances in Hematology


Volume 2012, Number 2012


Hindawi Publishing Corporation | 2011-08-11, Pages 1-7

Type of Work:

Article | Final Publisher PDF

Abstract: Significant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia JMML have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targeted therapies for this otherwise fatal disease. Various approaches are being investigated to target defective pathways-molecules in this disease. However, effective therapy is still lacking. Development of specific target-based drugs for JMML remains a big challenge and represents a promising direction in this field.

Subjects: Health Sciences, Medicine and Surgery - Engineering, Biomedical - Research Funding: This work was supported by the National Institutes of Health Grants HL068212 and HL095657 to C.-K. Q., DK059380 to K. D. Bunting, Cure Childhood Cancer Foundation to K. D. Bunting and H. Sabnis, Rally Foundation for Childhood Cancer Research to K. D. Bunting, and the Case Comprehensive Cancer Center Cancer Stem Cell Pilot Grant to C.-K. Qu. X. Liu and H. Sabnis contributed equally to this paper.

Autor: Xiaoling Liu, Himalee Sabnis, Kevin Bunting, Cheng-Kui Qu,



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