Effects of Peripapillary Scleral Stiffening on the Deformation of the Lamina CribrosaReport as inadecuate

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Journal Title:

Investigative Ophthalmology and Visual Science


Volume 57, Number 6


Association for Research in Vision and Ophthalmology ARVO | 2016-05-01, Pages 2666-2677

Type of Work:

Article | Final Publisher PDF

Abstract: PURPOSE. Scleral stiffening has been proposed as a treatment for glaucoma to protect the lamina cribrosa LC from excessive intraocular pressure-induced deformation. Here we experimentally evaluated the effects of moderate stiffening of the peripapillary sclera on the deformation of the LC. METHODS. An annular sponge, saturated with 1.25% glutaraldehyde, was applied to the external surface of the peripapillary sclera for 5 minutes to stiffen the sclera. Tissue deformation was quantified in two groups of porcine eyes, using digital image correlation DIC or computed tomography imaging and digital volume correlation DVC. In group A n = 14, eyes were subjected to inflation testing before and after scleral stiffening. Digital image correlation was used to measure scleral deformation and quantify the magnitude of scleral stiffening. In group B n = 5, the optic nerve head region was imaged using synchrotron radiation phase-contrast microcomputed tomography PC µCT at an isotropic spatial resolution of 3.2 lm. Digital volume correlation was used to compute the full-field threedimensional deformation within the LC and evaluate the effects of peripapillary scleral crosslinking on LC biomechanics. RESULTS. On average, scleral treatment with glutaraldehyde caused a 34 ± 14% stiffening of the peripapillary sclera measured at 17 mm Hg and a 47 ± 12% decrease in the maximum tensile strain in the LC measured at 15 mm Hg. The reduction in LC strains was not due to cross-linking of the LC. CONCLUSIONS. Peripapillary scleral stiffening is effective at reducing the magnitude of biomechanical strains within the LC. Its potential and future utilization in glaucoma axonal neuroprotection requires further investigation.

Subjects: Engineering, Biomedical - Health Sciences, General - Research Funding: Supported by Science and Technology Facilities Council Grants EE8491, EE9825, and EE11407; the Georgia Research Alliance CRE; National Eye Institute Grant R01 EY025286 CRE; and the Department of Veterans Affairs IK1 RX001791-01 ICC.

Keywords: Science and Technology - Life Sciences and Biomedicine - Ophthalmology - biomechanics - phase contrast microcomputed tomography - digital image correlation - digital volume correlation - OPTIC-NERVE HEAD - COLLAGEN CROSS-LINKING - MANIFEST GLAUCOMA TRIAL - INTRAOCULAR-PRESSURE - MONKEY EYES - BIOMECHANICS - STRAIN - PROGRESSION - STRESS - DAMAGE -

Author: Baptiste Coudrillier, Ian C. Campbell, A. Thomas Read, Diogo M. Geraldes, Nghia T. Vo, Andrew Feola, John Mulvihill, Julie Albon,

Source: https://open.library.emory.edu/


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