Synthesis of N-{5-Aryl-1,3,4-oxadiazole-2-yl}methyl-4-methoxyaniline Derivatives and Their Anticonvulsant ActivityReportar como inadecuado




Synthesis of N-{5-Aryl-1,3,4-oxadiazole-2-yl}methyl-4-methoxyaniline Derivatives and Their Anticonvulsant Activity - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of ChemistryVolume 2013 2013, Article ID 121029, 7 pages

Research Article

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India

PG Department of Chemistry, JSS College of Arts, Commerce and Science, Ooty Road, Mysore 25, India

Received 12 May 2013; Accepted 27 June 2013

Academic Editor: Alberto Ritieni

Copyright © 2013 B. N. Prasanna Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of some new 2,5-disubstituted-1,3,4-oxadiazoles 4a–i have been conveniently synthesized by intramolecular oxidative cyclization of E-2-arylbenzylidene-2-4-methoxyphenylaminoacetohydrazides promoted by iodobenzene diacetate as an oxidant. The structures of the synthesized compounds have been confirmed by

H and

C NMR, IR, MS, and elemental analysis. All the newly synthesized compounds were screened for their anticonvulsant activity against maximal electroshock MES seizure method. Compounds 4g, 4d, and 4a were found to be the most potent of this series. The same compounds showed no neurotoxicity at the maximum dose administered.





Autor: B. N. Prasanna Kumar, K. N. Mohana, and L. Mallesha

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados