Role of Tumor Associated Fibroblasts in Human Liver Regeneration, Cirrhosis, and CancerReportar como inadecuado




Role of Tumor Associated Fibroblasts in Human Liver Regeneration, Cirrhosis, and Cancer - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

International Journal of HepatologyVolume 2011 2011, Article ID 120925, 15 pages

Research Article

Department of Medical and Biological Sciences, University of Udine, P.le Kolbe 3, 33100 Udine, Italy

Department of Pathology, University Hospital “S. Maria della Misericordia” of Udine, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy

University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, 44100 Ferrara, Italy

Department of Surgery, University Hospital “S. Maria della Misericordia” of Udine, Piazzale Santa Maria della Misericordia 15, 33100 Udine, Italy

Received 15 June 2011; Revised 22 August 2011; Accepted 22 August 2011

Academic Editor: Wolfram Trudo Knoefel

Copyright © 2011 Daniela Cesselli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tumor associated fibroblasts TAFs are considered a microenvironmental element critical for tumor growth and progression. Experimental studies suggest that their origin could be from mesenchymal stem cells MSCs derived from the bone marrow. However, the role played by TAFs in cirrhosis, hepatocellular carcinoma development, and progression is largely unknown, and in vitro human models are missing. This paper for the first time demonstrates that 1 human neoplastic livers possess a population of multipotent adult stem cells MASCs with properties of TAFs; 2 a population of MASC-derived TAFs is already present in cirrhotic, not yet neoplastic, livers; 3 MASCs isolated from nonneoplastic and noncirrhotic liver scan acquire a TAF phenotype when grown in a medium conditioned by tumor cell lines, supporting the notion that TAF could originate from resident primitive cells MASCs, possibly through a paracrine mechanism.





Autor: Daniela Cesselli, Antonio Paolo Beltrami, Alessandra Poz, Stefania Marzinotto, Elisa Comisso, Natascha Bergamin, Evgenia Bou

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados