Open Trial of Cyclosporine in Patients with Severe Active Crohns Disease Refractory to Conventional TherapyReport as inadecuate

Open Trial of Cyclosporine in Patients with Severe Active Crohns Disease Refractory to Conventional Therapy - Download this document for free, or read online. Document in PDF available to download.

Canadian Journal of Gastroenterology - Volume 2 1988, Issue 1, Pages 5-11

Clinical Gastroenterology Departments of Medicine and Surgery, Faculty of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada

Copyright © 1988 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License CC BY-NC, which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.


Fifteen patients with severe active Crohn-s disease, refractory to conventionaltherapy, were given a 16 week course of cyclosporine ar an initial oral dailydose of 10 mg-kg, adjusted to maintain cyclosporine scrum trough levels between 100and 200 ng-ml. Five patients withdrew early because of side effects, poor absorption ornoncompliance. T he remaining 10 patients all improved within four weeks asmeasured by three different clinical indices: Crohn-s Disease Activity Index, SimpleIndex of Crohn-s Disease Activity and Mean Score of Therapeutic Goals MSTG.Seven patients maintained this initial improvement and prednisone was eitherreduced or discontinued. Four of these seven patients relapsed with in four weeks ofstopping cyclosporine, and three remain in remission after 75 ± 2 weeks. Side effectswere minor and easily reversible. When the various clinical and laboratory indiceswere compared, MSTG was found to be the most useful index for the assessment oftherapy. Cyclosporine appears to be a safe and effective therapy in patients with severeactive Crohn-s disease refractory to conventional therapy.

Author: Kevork M. Peltekian, C. Noel Williams, Allan S. MacDonald, Peter D. Roy, and Elizabeth Czolpinska



Related documents