Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet ActivityReportar como inadecuado

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BioMed Research International - Volume 2017 2017, Article ID 8715909, 9 pages - https:-doi.org-10.1155-2017-8715909

Research Article

Wrovasc-Integrated Cardiovascular Centre, Provincial Specialized Hospital, Kamieńskiego 73a, 51-124 Wroclaw, Poland

Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland

Department of Congenital Heart Diseases, Institute of Cardiology, Warsaw, Poland

Glostrup Research Institute, Glostrup, Denmark

Division of Respiratory, Critical Care and Sleep Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, SK, Canada

Correspondence should be addressed to Adrian Doroszko

Received 24 January 2017; Accepted 2 May 2017; Published 29 May 2017

Academic Editor: Vida Demarin

Copyright © 2017 Katarzyna Podgórska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of the study was to assess the impact of regular professional sports activity on the endothelial and platelet function in young men. The studied group were 79 young men 18–40 y, 25 athletes and 54 without any regular physical activity. The nitric oxide NO metabolic pathway intermediates, oxidative stress markers, mediators of inflammation, and platelet aggregation were measured. Flow mediated dilation FMD was studied before and after intravenous 16,0 g L-arginine infusion, which was repeated after oral administration of acetylsalicylic acid ASA-75 mg-day for 4 days. Both groups had similar demographic characteristics. In the athletes, there was significantly higher hsCRP level, better serum lipid profile, and lower pulse pressure. Greater baseline FMD in athletes and in response to L-arginine disappeared following ASA treatment. There were no differences in the levels of the NO pathway metabolites. The control group was characterized by higher PAI-1 following ASA treatment and sICAM-1 both at baseline and after ASA, but no differences in MDA and 6-keto-PGF-1 alpha and platelet aggregation were noted. Regular professional physical activity modulates endothelial but not platelet function and may thus exert an effect on overall cardiovascular risk.


Fuente: https://www.hindawi.com/


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