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Journal of OncologyVolume 2010 2010, Article ID 257058, 11 pages

Review Article

Division of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, QC, Canada H3T 1E2

Segal Cancer Center, Lady Davis Institute of Medical Research, McGill University, Montreal, QC, Canada H3T 1E2

Received 12 June 2009; Accepted 9 October 2009

Academic Editor: Charles F. Levenback

Copyright © 2010 Marie-Claude Beauchamp et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ovarian cancer is the most lethal of all gynecological malignancies, due in part to the diagnosis at an advanced stage caused by the lack of specific signs and symptoms and the absence of reliable tests for screening and early detection. Most patients will respond initially to treatment but about 70% of them will suffer a recurrence. Therefore, new therapeutic modalities are urgently needed to overcome chemoresistance observed in ovarian cancer patients. Evidence accumulates suggesting that the insulin-insulin growth factor IGF pathways could act as a good therapeutic target in several cancers, including ovarian cancer. In this paper, we will focus on the role of insulin-IGF in ovarian cancer tumorigenesis and treatment.





Autor: Marie-Claude Beauchamp, Amber Yasmeen, Ariane Knafo, and Walter H. Gotlieb

Fuente: https://www.hindawi.com/



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