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Advances in Pharmacological Sciences - Volume 2015 2015, Article ID 257057, 6 pages -

Research Article

Department of Pharmacology, Dongguk University, Gyeongju 780-714, Republic of Korea

Department of Systems Immunology, Kangwon National University, Chuncheon 200-701, Republic of Korea

Department of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea

Department of Pharmacy, International Islamic University Chittagong, Chittagong 4203, Bangladesh

Department of Systems Biotechnology, Chung-Ang University, Anseong 456-756, Republic of Korea

Received 30 April 2015; Revised 7 July 2015; Accepted 8 July 2015

Academic Editor: Antonio Ferrer-Montiel

Copyright © 2015 Md. Khalilur Rahman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diarrhea is one of the most common causes for thousands of deaths every year. Therefore, identification of new source of antidiarrheal drugs becomes one of the most prominent focuses in modern research. Our aim was to investigate the antidiarrheal and cytotoxic activities of methanolic extract of Maranta arundinacea linn. MEMA leaves in rats and brine shrimp, respectively. Antidiarrheal effect was evaluated by using castor oil-induced diarrhea, enteropooling, and gastrointestinal motility tests at 200 mg-kg and 400 mg-kg body weight in rats where the cytotoxic activity was justified using brine shrimp lethality bioassay at different concentrations of MEMA. The extract showed considerable antidiarrheal effect by inhibiting 42.67% and 57.75% of diarrheal episode at the doses of 200 and 400 mg-kg, respectively. MEMA also significantly reduced the castor oil-induced intestinal volume 2.14 ± 0.16 to 1.61 ± 0.12 mL in enteropooling test as well as intestinal transit 33.00 to 43.36% in GI motility test, compared to their respective control. These observed effects are comparable to that of standard drug loperamide 5 mg-kg. On the other hand, in brine shrimp lethality test after 24 h, surviving brine shrimp larvae were counted and LD50 was assessed. Result showed that MEMA was potent against brine shrimp with LD50 value of 420 µg-mL. So the highest dose of 400 µg-mL of MEMA was not toxic to mice. So these results indicate that bioactive compounds are present in methanolic extract of Maranta arundinacea leaves including significant antidiarrheal activity and could be accounted for pharmacological effects.





Autor: Md. Khalilur Rahman, Md. Ashraf Uddin Chowdhury, Mohammed Taufiqual Islam, Md. Anisuzzaman Chowdhury, Muhammad Erfan Uddin, a

Fuente: https://www.hindawi.com/



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