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BioMed Research International - Volume 2015 2015, Article ID 257030, 8 pages -

Research Article

School of Computer Science and Information Technology, Northeast Normal University, Changchun 130117, China

National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China

Key Laboratory of Intelligent Information Processing of Jilin Universities, Northeast Normal University, Changchun 130117, China

Faculty of Physical Education, Northeast Normal University, Changchun 130024, China

Received 4 May 2014; Revised 8 November 2014; Accepted 11 November 2014

Academic Editor: Florencio Pazos

Copyright © 2015 Pingping Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Identification of epitopes which invokes strong humoral responses is an essential issue in the field of immunology. Various computational methods that have been developed based on the antigen structures and the mimotopes these years narrow the search for experimental validation. These methods can be divided into two categories: antigen structure-based methods and mimotope-based methods. Though new methods of the two kinds have been proposed in these years, they cannot maintain a high degree of satisfaction in various circumstances. In this paper, we proposed a new conformational B-cell epitope prediction method based on antigen preprocessing and mimotopes analysis. The method classifies the antigen surface residues into “epitopes” and “nonepitopes” by six epitope propensity scales, removing the “nonepitopes” and using the preprocessed antigen for epitope prediction based on mimotope sequences. The proposed method gives out the mean F score of 0.42 on the testing dataset. When compared with other publicly available servers by using the testing dataset, the new method yields better performance. The results demonstrate the proposed method is competent for the conformational B-cell epitope prediction.





Autor: Pingping Sun, Haixu Ju, Baowen Zhang, Yu Gu, Bo Liu, Yanxin Huang, Huijie Zhang, and Yuxin Li

Fuente: https://www.hindawi.com/



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