Comparative Activity of Daptomycin and Teicoplanin against Enterococci Isolated from Blood and UrineReportar como inadecuado

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Canadian Journal of Infectious Diseases - Volume 3 1992, Issue 4, Pages 173-178

Original Article Departments of Medicine and Laboratory Medicine, St Boniface General Hospital, Winnipeg, Manitoba, Canada

Received 27 July 1990; Accepted 21 February 1991

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The authors compared the activity of daptomycin with that of ampicillin, penicillin, teicoplanin and vancomycin against 304 strains of Enterococcus species isolated from blood and urine. Daptomycin was as active as penicillin against Enterococcus faecalis: 90% of strains were inhibited by 2 mg-L. Daptomycin was more active than vancomycin 90% minimal inhibitory concentration MIC90 2 mg-L; 90% minimal bactericidal concentration MBC90 8 mg-L but was less active than teicoplanin MIC50 0.25; MBC90 8 mg-L or ampicillin MIC90 1 mg-L; MBC90 2 mg-L against E faecalis. In time-kill studies daptomycin was not more rapidly bactericidal than ampicillin or penicillin but was significantly more rapidly bactericidal than either teicoplanin or vancomycin. In combination with gentamicin, daptomycin has activity similar to that of penicillin, vancomycin and teicoplanin. Daptomycin may be a suitable alternative to penicillin in patients allergic to penicillins or for the treatment of enterococcal infections caused by beta-lactamase-producing enterococci.

Autor: Kevin R Forward, Patricia DeGagne, Kathryn R Bartlett, and Godfrey K Harding



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