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BioMed Research InternationalVolume 2013 2013, Article ID 837120, 7 pages

Review Article

Neurology Department, University of São Paulo School of Medicine, Brazil

Gerontology Department, School of Arts, Sciences and Humanities of the University of São Paulo, Avenida Dr. Eneas de Carvalho Aguiar 255, 05403-900 São Paulo, SP, Brazil

Received 14 April 2013; Accepted 20 September 2013

Academic Editor: Cristiano Capurso

Copyright © 2013 Thais Bento Lima-Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim was to conduct a systematic review of studies that described the functional profile of patients with behavioral variant frontotemporal dementia bvFTD, published between 2000 and 2013. The bibliographic search was conducted using the terms “frontotemporal dementia” and “frontotemporal lobar degeneration” in combination with “independence,” “functionality,” “basic activities of daily living,” “disability,” and scales that measure functional performance: “Disability Assessment for Dementia-DAD,” “Functional Activities Questionnaire FAQ,” “Direct Assessment of Functional Status DAFS.” To be included in the review, the study had to mention the characterization of the functional status of patients with bvFTD in the objectives of the study, using a previously validated instrument of functional assessment. Fourteen studies met this criterion. The reviewed studies suggested that individuals with bvFTD have greater functional impairment when compared to those with other subtypes of frontotemporal lobar degeneration or Alzheimer’s disease. The studies documented a significant association between cognitive impairment and measures of functionality in these patients. The cognitive profile of patients may predict faster functional decline.

Autor: Thais Bento Lima-Silva, Valéria Santoro Bahia, Ricardo Nitrini, and Mônica Sanches Yassuda



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