18F-FDG silicon photomultiplier PET-CT: A pilot study comparing semi-quantitative measurements with standard PET-CTReportar como inadecuado




18F-FDG silicon photomultiplier PET-CT: A pilot study comparing semi-quantitative measurements with standard PET-CT - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Purpose

To evaluate if the new Discovery Molecular Insights DMI PET-CT scanner provides equivalent results compared to the standard of care PET-CT scanners GE Discovery 600 or GE Discovery 690 used in our clinic and to explore any possible differences in semi-quantitative measurements.

Methods

The local Institutional Review Board approved the protocol and written informed consent was obtained from each patient. Between September and November 2016, 50 patients underwent a single 18F-FDG injection and two scans: the clinical standard PET-CT followed immediately by the DMI PET-CT scan. We measured SUVmax and SUVmean of different background organs and up to four lesions per patient from data acquired using both scanners.

Results

DMI PET-CT identified all the 107 lesions detected by standard PET-CT scanners, as well as additional 37 areas of focal increased 18F-FDG uptake. The SUVmax values for all 107 lesions ranged 1.2 to 14.6 mean ± SD: 2.8 ± 2.8, higher on DMI PET-CT compared with standard of care PET-CT. The mean lesion:aortic arch SUVmax ratio and mean lesion:liver SUVmax ratio were 0.2–15.2 mean ± SD: 3.2 ± 2.6 and 0.2–8.5 mean ± SD: 1.9 ± 1.4 respectively, higher on DMI PET-CT than standard PET-CT. These differences were statistically significant P value < 0.0001 and not correlated to the delay in acquisition of DMI PET data P < 0.0001.

Conclusions

Our study shows high performance of the new DMI PET-CT scanner. This may have a significant role in diagnosing and staging disease, as well as for assessing and monitoring responses to therapies.



Autor: Lucia Baratto , Sonya Young Park, Negin Hatami, Guido Davidzon, Shyam Srinivas, Sanjiv Sam Gambhir, Andrei Iagaru

Fuente: http://plos.srce.hr/



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