Rs12970134 near MC4R is associated with appetite and beverage intake in overweight and obese children: A family-based association study in Chinese populationReportar como inadecuado




Rs12970134 near MC4R is associated with appetite and beverage intake in overweight and obese children: A family-based association study in Chinese population - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Recent studies indicated that eating behaviors are under genetic influence, and the melanocortin 4 receptor MC4R gene polymorphisms can affect the total energy intake and the consumption of fat, protein and carbohydrates. Our study aims at investigating the association of the MC4R polymorphism with appetite and food intake among Chinese children.

Methods

A family-based association study was conducted among 151 Chinese trios whose offsprings were overweight-obese children aged 9–15 years. The rs12970134 near MC4R was genotyped, and the Children Eating Behavior Questionnaire CEBQ and a self-designed questionnaire measuring food intake were performed. The FBAT and PBAT software packages were used.

Results

The family-based association analysis showed that there was a significant association between rs12970134 and obesity Z = 2.449, P = 0.014. After adjusting for age, gender and standardized BMI, rs12970134 was significantly associated with food responsiveness FR among children β-b = 0.077, Pb = 0.028, and with satiety responsiveness SR in trios P = -0.026. The polymorphism was associated with beverage intake β-b = 0.331, Pb = 0.00016 in children; P = 0.043 in trios, but not significantly associated with vegetable, fruit or meat intake P>0.050. We further found a significant mediation effect among the rs12970134, FR and beverage intake b = 0.177, P = 0.047.

Conclusions

Our study is the first to report that rs12970134 near MC4R was associated with appetite and beverage intake, and food responsiveness could mediate the effect of rs12970134 on beverage intake in overweight and obese Chinese children population. Further studies are needed to uncover the genetic basis for eating behaviors, which could lead to develop and implement effective interventional strategies early in life.



Autor: Shuo Wang, Jieyun Song, Yide Yang, Nitesh V. Chawla, Jun Ma , Haijun Wang

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados