Genetic variations in sterol regulatory element binding protein cleavage-activating protein SCAP are associated with blood pressure in overweight-obese Chinese childrenReportar como inadecuado




Genetic variations in sterol regulatory element binding protein cleavage-activating protein SCAP are associated with blood pressure in overweight-obese Chinese children - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Objective

Previous studies demonstrated a role of variations in sterol regulatory element binding protein SREBP cleavage-activating protein SCAP in obesity and blood lipids. But the associations between SCAP polymorphisms and blood pressure BP are not clear. This study aimed to investigate the relationship between genetic variations in SCAP and BP phenotypes in a Chinese pediatric population.

Methods

A case-control study on 702 high blood pressure HBP children and 1319 controls was conducted to explore the correlation between single nucleotide polymorphism markers rs12487736 and rs12490383 of SCAP and BP phenotypes. The associations with continuous and categorical variables were examined by linear regression and logistic regression models under a dominant genetic model for the minor rs12487736 A allele and rs12490383 T allele.

Results

The rs12487736 polymorphism was significantly associated with systolic BP SBP β = 1.66, P = 0.003 and diastolic BP DBP β = 1.35, P = 0.024 with age, age-squared, sex, study population and body mass index BMI adjusted under the dominant genetic model. The rs12490383 polymorphism was significantly associated with SBP β = 1.71, P = 0.004 and SHBP OR = 1.39, 95%CI: 1.04–1.86, P = 0.027. When analyzed by BMI categories, in the normal-weight children, no significant association between the SCAP polymorphisms and BP phenotypes was observed all P > 0.05. However, in the overweight-obese children, rs12487736 was significantly associated with SBP β = 1.6, P = 0.019 and SHBP OR = 1.36, 95%CI: 1.02–1.82; P = 0.037, rs12490383 was associated with SBP β = 2.04, P = 0.004 and SHBP OR = 1.50, 95%CI: 1.10–2.05; P = 0.01.

Conclusions

This study demonstrated that SCAP rs12487736 and rs12490383 were significantly associated with SBP and SHBP in overweight-obese Chinese children. It provided the evidence for association of SCAP with SBP.



Autor: Yi-De Yang, Jie-Yun Song, Shuo Wang, Fang-Hong Liu, Yi-Ning Zhang, Xiao-Rui Shang, Hai-Jun Wang , Jun Ma

Fuente: http://plos.srce.hr/



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