An elevated serum alkaline phosphatase level in hepatic metastases of grade 1 and 2 gastrointestinal neuroendocrine tumors is unusual and of prognostic valueReportar como inadecuado




An elevated serum alkaline phosphatase level in hepatic metastases of grade 1 and 2 gastrointestinal neuroendocrine tumors is unusual and of prognostic value - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

In our clinical practice we have observed that despite a high hepatic metastatic tumor burden, serum alkaline phosphatase AP levels are frequently normal in cases of metastatic neuroendocrine tumor NET.

Patients and methods

We retrospectively reviewed the records of patients with grade 1 and 2 NETs with liver metastases but without bone metastases seen at our institution in 2013. In total, 49 patients were included 22 female, with a median age of 60 years range: 28 to 84 years. The primary tumors were located in the duodenum-pancreas n = 29, small bowel n = 17 or colon-rectum n = 3; 10 cases were grade 1 and 39 grade 2. Hepatic involvement was bulky, with more than 10 lesions in 23 patients and a tumor burden above 10% of the liver volume in 26 patients.

Results

Serum AP levels were elevated ≥ upper limit of normal ULN in 16 patients. In multiparametric analysis, elevated serum AP levels were not associated with the primary site, grade, or number or volume of metastases. In multiparametric analysis, progression-free survival was only correlated with grade p = 0.010 and AP level p = 0.017.

Conclusions

Serum AP levels are frequently normal in liver metastases from NET, even in the event of a major tumor burden, and the serum AP level can be of prognostic value.



Autor: Maeva Andriantsoa, Solene Hoibian, Aurelie Autret, Marine Gilabert, Anthony Sarran, Patricia Niccoli, Jean-Luc Raoul

Fuente: http://plos.srce.hr/



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