Surveillance of impact of PCV-10 vaccine on pneumococcal meningitis in Mozambique, 2013 – 2015Report as inadecuate




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Background

Vaccination using the 10-valent conjugate vaccine PCV-10 was introduced into the Extended Program on Immunization in Mozambique in March 2013, however its impact on pediatric pneumococcal meningitis is unknown. In this study, we assessed for the first time the impact of PCV10 on the burden of pneumococcal meningitis in children less than 5 years of age at the three largest hospitals in Mozambique.

Method

Between March 2013 and December 2015, a total of 744 cerebrospinal fluid CSF samples were collected from eligible children, of which 160 21.5% were positive for S. pneumoniae. Of these, only 86 samples met the criteria for serotyping and were subsequently serotyped using sequential multiplex PCR SM-PCR, but 17 samples were non-typable.

Results

The proportion of cases of pneumococcal meningitis decreased from 33.6% 124 of 369 in 2013 to 1.9% 3 of 160 in 2015 p < 0.001. The relative frequency of PCV10 serotype cases also decreased from 84.2% 48 of 57 in 2013 to 0% 0 of 3 in 2015 p = 0.006. Between 2013 and 2015, serotype coverage of PCV-10 and PCV13 vaccine formulations was 66.7% and 81.2%, respectively.

Conclusion

Altogether, our findings shows that introduction of PCV-10 immunization resulted in rapid decline of pneumococcal meningitis children less than 5 years old in Mozambique. This decline was accompanied by substantial changes in the pattern of circulating pneumococcal serotypes.



Author: Aquino Albino Nhantumbo , Goitom Weldegebriel, Reggis Katsande, Linda de Gouveia, Charlotte Elizabeth Comé, Arlindo Zacarias Cuc

Source: http://plos.srce.hr/



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