Cavum septum pellucidum and first-episode psychosis: A meta-analysisReport as inadecuate




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Objectives

To investigate the prevalence and changes of cavum septum pellucidum CSP in first-episode psychosis FEP patients.

Methods

Medline, Embase, and the Cochrane Central Register of Controlled Trials CENTRAL were searched to identify eligible studies comparing FEP patients and healthy controls from inception to Feb 29, 2016.

Results

Ten cross-sectional studies and three longitudinal studies reported in ten articles met our criteria. Our meta-analysis found no significant differences in the prevalence of either -any CSP- OR = 1.41; 95% CI 0.90–2.20; p = 0.13; I2 = 52.7% or -large CSP- OR = 1.10; 95% CI 0.77–1.58; p = 0.59; I2 = 24.1% between FEP patients and healthy controls. However, the heterogeneity analysis of the prevalence of -any CSP- suggested bias in outcome reporting.

Conclusions

The results based on current evidence suggest it is unclear whether -any CSP- is a risk factor for FEP due to the heterogeneity of the studies. There is insufficient evidence to support that -large CSP- is a possible risk factor for FEP.



Author: Hanwen Liu, Ling Li, Li Shen, Xianliang Wang, Yazhu Hou, Zhiqiang Zhao, Lili Gu, Jingyuan Mao

Source: http://plos.srce.hr/



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