Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysisReport as inadecuate

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Background and aim

As there is conflicting evidence for the relationship between hepatitis B virus surface antigen HBsAg positivity and the prevalence of metabolic syndrome MetS, we performed a meta-analysis to investigate whether HBsAg positivity affects the incidence of MetS.


Observational studies on the relationship between HBsAg positivity and MetS were obtained from PubMed, Web of Science, and the Cochrane Library in April 2016. The pooled odds ratios ORs of MetS and its components central obesity, increased fasting glucose, increased blood pressure, dyslipidemia for subjects with or without HBsAg positivity were synthesized. The standardized mean difference of MetS components between HBsAg-positive participants and healthy controls was calculated. Heterogeneity was explored with subgroup analysis and sensitivity analysis. Publication bias was detected using Egger’s test and Begg’s test.


Thirty studies were eligible for meta-analysis. The MetS OR for HBsAg-positive participants was significantly decreased compared with the controls OR = 0.80, 95% confidence interval CI, 0.70–0.90. The negative effect of HBsAg positivity on elevated triglycerides OR = 0.62, 95% CI, 0.59–0.64 was strong, while that for increased fasting blood glucose was weak OR = 0.94, 95% CI, 0.90–0.98. The pooled ORs of central obesity OR = 0.97, 95% CI, 0.91–1.04, reduced high-density lipoprotein cholesterol OR = 0.98, 95% CI, 0.83–1.14, and elevated blood pressure OR = 1.00, 95% CI, 0.80–1.25 for HBsAg-positive participants were all not significantly different compared with the controls. No publication bias was detected.


Serum HBsAg positivity is inversely associated with the prevalence of MetS. Among the five components of MetS, elevated triglycerides had the strongest inverse relationship with HBsAg positivity.

Author: Yuanyuan Li, Ying Zhao, Jianping Wu



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