Inflammatory biomarkers as predictors of heart failure in women without obstructive coronary artery disease: A report from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation WISEReport as inadecuate




Inflammatory biomarkers as predictors of heart failure in women without obstructive coronary artery disease: A report from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation WISE - Download this document for free, or read online. Document in PDF available to download.

Background

Women with signs and symptoms of ischemia, no obstructive coronary artery disease CAD and preserved left ventricular ejection fraction EF often have diastolic dysfunction and experience elevated rates of major adverse cardiac events MACE, including heart failure HF hospitalization with preserved ejection fraction HFpEF. We evaluated the predictive value of inflammatory biomarkers for long-term HF hospitalization and all-cause mortality in these women.

Methods

We performed a cross-sectional analysis to investigate the relationships between inflammatory biomarkers serum interleukin-6 IL-6, C-reactive protein hs-CRP and serum amyloid A SAA and median of 6 years follow-up for all-cause mortality and HF hospitalization among women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF. Multivariable Cox regression analysis tested associations between biomarker levels and adverse outcomes.

Results

Among 390 women, mean age 56 ± 11 years, median follow up of 6 years, we observed that there is continuous association between IL-6 level and HF hospitalization adjusted hazard ratio AHR 2.5 1.2–5.0, p = 0.02. In addition, we found significant association between IL-6, SAA levels and all-cause mortality AHR 1.8 1.1–3.0, p = 0.01 1.5 1.0–2.1, p = 0.04, respectively.

Conclusion

In women with signs and symptoms of ischemia, non-obstructive CAD and preserved EF, elevated IL-6 predicted HF hospitalization and all-cause mortality, while SAA level was only associated with all-cause mortality. These results suggest that inflammation plays a role in the pathogenesis of development of HFpEF, as well all-cause mortality.



Author: Ahmed AlBadri, Kha Lai, Janet Wei, Sofy Landes, Puja K. Mehta, Quanlin Li, Delia Johnson, Steven E. Reis, Sheryl F. Kelsey, Vera

Source: http://plos.srce.hr/



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