Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat—Experimental observations and mathematical modelingReport as inadecuate




Corticosterone oscillations during mania induction in the lateral hypothalamic kindled rat—Experimental observations and mathematical modeling - Download this document for free, or read online. Document in PDF available to download.

Changes in the hypothalamic-pituitary-adrenal HPA axis activity constitute a key component of bipolar mania, but the extent and nature of these alterations are not fully understood. We use here the lateral hypothalamic-kindled LHK rat model to deliberately induce an acute manic-like episode and measure serum corticosterone concentrations to assess changes in HPA axis activity. A mathematical model is developed to succinctly describe the entwined biochemical transformations that underlay the HPA axis and emulate by numerical simulations the considerable increase in serum corticosterone concentration induced by LHK. Synergistic combination of the LHK rat model and dynamical systems theory allows us to quantitatively characterize changes in HPA axis activity under controlled induction of acute manic-like states and provides a framework to study in silico how the dynamic integration of neurochemical transformations underlying the HPA axis is disrupted in these states.



Author: Osama A. Abulseoud , Man Choi Ho, Doo-Sup Choi, Ana Stanojević, Željko Čupić, Ljiljana Kolar-Anić, Vladana Vukojević

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents