Decreased health-related quality of life in angiodysplasia patients: A cross-sectional cohortReport as inadecuate

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Gastrointestinal angiodysplasias may cause anemia. Quality of life QoL is a valid patient reported outcome and improvement of QoL represents an important treatment goal. There is a paucity of data on the effect of angiodysplasias on QoL. Therefore, we aim to evaluate QoL and fatigue in angiodysplasia patients. We performed a cross-sectional patient-reported outcome study. We included patients with endoscopy proven angiodysplasias and measured QoL with Short Form-36 and level of fatigue using Multi Fatigue Inventory-20. We distinguished three subgroups of patients according to disease severity: 1 with treatment for angiodysplasias, 2 without treatment for angiodysplasias and 3 without recent hospital visits. The primary outcome was the physical component summary PCS score on the SF-36. Multivariate regression analysis were performed to correct for differences at baseline. A total of 144 patients completed the questionnaires response rate = 62%; mean age 68 years; 65% men. Angiodysplasia patients have a significant lower PCS compared to the age-matched general population respectively 41.0 vs. 43.3, p = 0.01. Disease severity is independently associated with a negative outcome on QoL ß -4.6, 95% CI -7.8–-1.3. Similarly patients score lower on multiple QoL subdomains, i.e. role limitations due to physical health problems 40.8 vs. 44.0, p<0.01, general health 39.7 vs. 47.3, p<0.01. Angiodysplasia patients are more fatigued compared to the general population male 56.1 vs. 48.5, p<0.01, female 59.2 vs. 51.5, p = 0.01. In conclusion, angiodysplasias are independently associated with clinically significant impairments in multiple domains of health-related QoL, especially in measures of functional limitation.

Author: Karina V. Grooteman , Mijntje Matheeuwsen, Erwin J. M. van Geenen, Joost P. H. Drenth



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