Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinomaReport as inadecuate




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Chronic inflammation is a well-known epidemiologic factor of ovarian clear cell carcinomas OCCC, but has an uncertain role in prognosis. We developed a systemic inflammation score SIS based on preoperative serum albumin and neutrophil-to-lymphocyte ratio NLR for predicting progression-free survival PFS and overall survival OS in OCCC patients. A retrospective review was performed in 155 patients with OCCC undergoing primary debulking and chemotherapy at a single institute between 1995 and 2010. Cox regression models were fitted to analyze the effect of prognostic factors on PFS and OS. Harrell’s concordance index was calculated to assess predictive accuracy. The SIS consisting of serum albumin and NLR was retained as an independent indicator adjusting for traditional clinicopathological features. A high SIS was significantly associated with aggressive tumor behavior, platinum resistance, and served as an independent predictor of reduced PFS P = 0.006 and OS P = 0.019. The SIS had a good discrimination ability for the predictive PFS c-index = 0.712 and OS c-index = 0.722. We have developed a system inflammation score for predicting prognosis of OCCC patients, which may help stratify patients for postsurgical management.



Author: Hongwei Zhang , Jiaqi Lu , Yingying Lu, Jiayi Zhou, Zehua Wang, Haiou Liu , Congjian Xu

Source: http://plos.srce.hr/



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