Insulin resistance contributes more to the increased risk for diabetes development in subjects with low lipoproteina level than insulin secretionReport as inadecuate




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Background

Recent studies suggest an association between Lipoproteina Lpa and the development of diabetes mellitus. We analyzed the association between baseline Lpa levels and diabetes development after 4 years of follow-up, in a population of apparently healthy Korean subjects.

Methods

A total of 2,536 non-diabetic participants mean age: 41 years, men: 92% of a health checkup program were included in the study. Diabetes development was defined by fasting blood glucose ≥126 mg-dL, HbA1c ≥6.5%, and self-reported treatment of diabetes. Homeostasis model assessment HOMA indices were used to assess insulin resistance IR and insulin secretion IS. Presence of IR and impaired IS was defined by being in the highest quartile of HOMA-IR and in the lowest quartile HOMA-IS.

Results

After four years, 3.4% of the participants developed diabetes. The odds ratio OR of developing diabetes was lowest in the 4th quartile group of baseline Lpa 0.323 95% CI 0.153–0.685with the 1st quartile group as the reference. The subjects with both IR and impaired IS plus baseline Lpa<50 mg-dL showed the higher OR for diabetes development compared with those without IR and normal IS as the reference 67.277 20.218–223.871, and those with IR plus Lpa<50 mg-dL showed higher OR for diabetes than in those with impaired IS and Lpa<50 mg-dL 3.811 1.938–7.495 vs. 3.452 1.620–7.353.

Conclusions

The subjects with low baseline Lpa level showed higher risk for development of diabetes compared with high baseline Lpa level, and this was prominent in those with IR than in those with impaired IS.



Author: Eun-Jung Rhee, Jung Hwan Cho, Da Young Lee, Hyemi Kwon, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee

Source: http://plos.srce.hr/



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