Perinatal outcomes and congenital heart defect prognosis in 53313 non-selected perinatal infantsReport as inadecuate

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To evaluate perinatal outcomes and congenital heart defect CHD prognosis in a non-selected population.


The population-based surveillance data used in this assessment of CHDs were based on birth defect surveillance data collected from 2010–2012 in Liuyang City, China. Infants living with CHDs were followed up for 5 years to determine their prognosis. Prevalence, prenatal diagnosis, perinatal outcomes, and total and type-specific prognosis data were assessed using SPSS 18.0.


In total, 190 CHD cases were identified among the 53313 included perinatal infants PIs, indicating a CHD prevalence of 35.64 per 10000 PIs in this non-selected population. The five most frequently identified types of CHDs were ventricular septal defects VSDs, 38.95%, atrial septal defects ASDs, 15.79%, cardiomegaly 7.89%, tetralogy of Fallot TOF, 5.79%, and atrioventricular septal defects AVSDs, 5.26%. Of the 190 CHD cases, 110 57.89% were diagnosed prenatally, 30 15.79% were diagnosed with associated malformations, and 69 36.32% resulted in termination of pregnancy TOP. Moreover, 15 7.89% PIs died within 7 days after delivery, and 42 22.10% died within 1 year. In contrast, 79 41.58% were still alive after 5 years. When TOP cases were included, the 5-year survival rate of PIs with prenatally detected CHDs was lower than that of PIs with postnatally detected CHDs 25.45% vs. 63.75%. The CHD subtype associated with the highest rate of infant less than 1 year old mortality was transposition of the great arteries 100%. The subtypes associated with higher 5-year survival rates were patent ductus arteriosus 80%, ASD 63.33%, VSD 52.70% and AVSD 50%.


The rates of prenatal CHD detection and TOP were high in this study population, and the 5-year survival rate of PIs with CHDs was low. The government should strengthen efforts to educate pediatricians regarding this issue and provide financial assistance to improve the prognosis of infants living with CHDs, especially during the first year of life.

Author: Donghua Xie, Hua Wang , Zhiyu Liu , Junqun Fang, Tubao Yang, Shujin Zhou, Aihua Wang, Jiabi Qin, Lili Xiong



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