Spontaneous clearance of chronic hepatitis C is rare in HIV-infected patients after effective use of combination antiretroviral therapyReport as inadecuate




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Objective

To evaluate the rate of spontaneous resolution of chronic hepatitis C CHC infection in a cohort of HIV-infected patients.

Methods

A retrospective analysis of 509 HIV-infected patients with chronic HCV infection was performed at two reference hospitals in Andalusia. The main variable of the study was spontaneous clearance of CHC, defined as a negative HCV RNA result after at least two previous quantitative measurements of HCV RNA separated by a minimum of 12 months.

Results

Of 509 patients, 3 0.59%; 95% CI: 0.15%-1.6% experienced spontaneous clearance of CHC. After combination antiretroviral therapy cART initiation, two of three cases experienced an increased CD4+ count, coinciding with HCV viral clearance. All patients were IL28B CC carriers, 2 were co-infected with HCV genotype 3 the HCV genotype of the remaining patient was not available.

Conclusions

Spontaneous clearance of CHC is a rare event in the context of HIV-HCV co-infected patients and may be associated with the effective use of cART and thus HIV suppression.



Author: Mario Frias, Antonio Rivero-Juarez, Francisco Tellez, Monserrat Perez-Perez, Angela Camacho, Isabel Machuca, Sandra Lorenzo-Monca

Source: http://plos.srce.hr/



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