Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – The Dialong hand studyReport as inadecuate




Long term type 1 diabetes is associated with hand pain, disability and stiffness but not with structural hand osteoarthritis features – The Dialong hand study - Download this document for free, or read online. Document in PDF available to download.

Objective

To explore whether having long-term type 1 diabetes >45 years is associated with a higher prevalence of radiographic hand OA, erosive hand OA and increased hand pain, disability and stiffness.

Methods

In total N = 96 persons with type 1 diabetes diagnosed before 1970 were included mean SD age: 62.2 7.4, mean SD HbA1c: 7.43 0.80 and N = 49 51% men. Regular measurements of their HbA1c were obtained till 2015. We included N = 69 healthy controls without any diabetes mean SD age: 63.0 7.0, mean SD HbA1c: 5.41 0.32, N = 29 42% men. The groups were compared for radiographic hand OA Kellgren-Lawrence grade ≥2 in ≥1 joint and erosive hand OA central erosions in ≥1 joint, Australian-Canadian index AUSCAN for hand pain, disability and stiffness using regression analyses adjusted for age, sex, educational level and waist circumference.

Results

We found no associations between having long term type 1 diabetes and more prevalent radiographic hand OA OR = 0.83, 95% CI = 0.38–1.81. We found a trend towards higher prevalence of erosive hand OA in diabetes patients OR = 2.96, 95% CI = 0.82–10.64. Strong and consistent associations were observed between long term type 1 diabetes and increased hand pain B = 2.78, 95% CI = 1.65–3.91, disability B = 5.30, 95% CI = 3.48–7.12 and stiffness B = 2.00, 95% CI = 1.33–2.67. These associations were particularly strong for women and participants below the median age of 61 years.

Conclusion

Long-term type 1 diabetes was not associated with radiographic hand OA, but was strongly associated with hand pain, disability and stiffness. The association between diabetes and erosive hand OA warrants further investigation.



Author: Karin Magnusson , Kristine Bech Holte, Niels Gunnar Juel, Jens Ivar Brox, Kåre Birger Hagen, Ida Kristin Haugen, Tore Julsrud Be

Source: http://plos.srce.hr/



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