OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devicesReport as inadecuate

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To compare the quality of four OCT-angiographyOCT-A modules.


The retina of nineteen healthy volunteers were scanned with four OCT-devices Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT. The device-software generated en-face OCT-A images of the superficial SCP and deep capillary plexuses DCP were evaluated and scored by 3 independent retinal imaging experts. The SCP vessel density was assessed using Angiotool-software. After the inter-grader reliability assessment, a consensus grading was performed and the modules were ranked based on their scoring.


There was no significant difference in the vessel density among the modules Zeiss 48.7±4%, Optovue 47.9±3%, Topcon 48.3±2%, Heidelberg 46.5±4%, p = 0.2. The numbers of discernible vessel-bifurcations differed significantly on each module Zeiss 2±0.9 bifurcations, Optovue 2.5±1.2, Topcon 1.3±0.7 and Heidelberg 0.5±0.6, p≤0.001. The ranking of each module differed depending on the evaluated parameter. In the overall ranking, the Zeiss module was superior and in 90% better than the median Bonferroni corrected p-value = 0.04. Optovue was better than the median in 60%, Topcon in 40% and Heidelberg module in 10%, however these differences were not statistically significant.


Each of the four evaluated OCT-A modules had particular strengths, which differentiated it from their competitors.

Author: Marion R. Munk , Helena Giannakaki-Zimmermann, Lieselotte Berger, Wolfgang Huf, Andreas Ebneter, Sebastian Wolf, Martin S. Zinker

Source: http://plos.srce.hr/


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