High fibroblast growth factor 23 levels are associated with decreased ferritin levels and increased intravenous iron doses in hemodialysis patientsReportar como inadecuado




High fibroblast growth factor 23 levels are associated with decreased ferritin levels and increased intravenous iron doses in hemodialysis patients - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

A recent study demonstrated the association between inflammation, iron metabolism and fibroblast growth factor FGF 23. The present clinical study aimed to assess associations between anemia, iron metabolism and FGF23 in hemodialysis HD patients. This prospective observational study examined a cohort of prevalent HD patients n = 282. Blood samples were obtained before dialysis sessions to measure baseline levels of hemoglobin Hb, transferrin saturation TSAT, ferritin, albumin-adjusted calcium Ca, phosphate P, intact i-PTH, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, intact i-FGF23, high sensitive hs-CRP, and interleukin-6. After the baseline measurement, study patients were followed-up for 6 months. Biochemical measurements were subsequently performed at 1 Hb, 2 TSAT and ferritin or 3 Ca, P and hs-CRP month intervals. Doses of ESAs and intravenous iron supplementation during the study period were recorded. i-FGF23 was positively correlated with Ca, P, i-PTH and inversely correlated with TSAT and ferritin. However, levels of Hb and hs-CRP and doses of ESAs during the study period did not differ among the i-FGF23 tertiles, with levels of ferritin and TSAT in the higher i-FGF23 tertile being consistently lower than in the middle to lower i-FGF23 tertiles. Multivariate repeated measures analysis indicated that the higher i-FGF23 tertile was independently associated with repeated measurements of ferritin, but not of TSAT. Doses of intravenous iron supplementation were significantly increased in the higher i-FGF23 tertile in multivariate models. In conclusion, high i-FGF23 levels may be associated with prolongation of low levels of ferritin, resulting in increased usages of iron supplementation in HD patients.



Autor: Hirokazu Honda , Tetsuo Michihata, Kanji Shishido, Keiko Takahashi, Go Takahashi, Nozomu Hosaka, Misa Ikeda, Daisuke Sanada, Taka

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados