Potential biological pathways linking Type-D personality and poor health: A cross-sectional investigationReportar como inadecuado




Potential biological pathways linking Type-D personality and poor health: A cross-sectional investigation - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Type-D personality, defined as a combination of high negative affect and high social isolation, has been associated with poor health outcomes. However, pathways underlying this association are largely unknown. We investigated the relationship between Type-D personality and several biological and behavioral pathways including the autonomic nervous system, the immune system, glucose regulation and sleep in a large, apparently healthy sample.

Methods

Data from a total of 646 respondents age 41.6±11.5, 12,2% women were available for analysis. Persons with Type-D negative affect and social isolation score ≥10 were contrasted with those without Type-D. Measures of plasma fibrinogen levels, white blood cell count, high sensitivity C-reactive protein, fasting plasma glucose FPG, cholesterol, high-density and low-density lipoprotein, glycated hemoglobin HbA1c, creatinine, triglycerides, and albumin were derived from fasting blood samples. Urine norepinephrine and free cortisol were determined by high-performance liquid chromatography. Time-domain heart rate variability HRV measures were calculated for the 24hr recording period and for nighttime separately.

Results

Persons with Type-D had higher HbA1c, FPG, and fibrinogen, and lower nighttime HRV than those without Type-D, suggesting worse glycemic control, systemic inflammation and poorer autonomic nervous system modulation in Type-D persons. In addition, those with Type-D reported less social support and greater sleep difficulties while no group differences were observed for alcohol and cigarette consumption, physical activity and body mass index.

Conclusions

Findings provide some of the first evidence for multiple possible biological and behavioral pathways between Type-D personality and increased morbidity and mortality.



Autor: Vera K. Jandackova, Julian Koenig, Marc N. Jarczok, Joachim E. Fischer, Julian F. Thayer

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados