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Background

Effect of prediabetes and normal glucose on arterial stiffness remains controversial. The primary aim of this study was to investigate the relationship of fasting plasma glucose FPG, postprandial glucose PG and glycosylated haemoglobin HbA1c with brachial-ankle pulse wave velocity baPWV and cardio-ankle vascular index CAVI in Caucasian adults. The secondary aim was to analyse this relationship by glycaemic status.

Methods

Cross-sectional study. Setting: Primary care. Participants: 2,233 subjects, 35–74 years. Measures: FPG mg-dL and HbA1c % of all subjects were measured using standard automated enzymatic methods. PG mg-dL was self-measured at home two hours after meals breakfast, lunch and dinner for one day using an Accu-chek ® glucometer. CAVI was measured using a VaSera VS-1500® device Fukuda Denshi, and baPWV was calculated using a validated equation.

Results

CAVI and baPWV values were significantly higher in subjects with diabetes mellitus than in glucose normal and prediabetes groups p<0.001. FPG, PG and HbA1c were positively associated with CAVI and baPWV. The β regression coefficient for: HbA1c was 0.112 CI 95% 0.068 to 0.155 with CAVI, 0.266 CI 95% 0.172 to 0.359 with baPWV; for PG was 0.006 CI 95% 0.004 to 0.009 and for FPG was 0.005 CI 95% 0.002 to 0.008 with baPWV; and for PG was 0.002 CI 95% 0.001 to 0.003 and 0.003 CI 95% 0.002 to 0.004 with CAVI p<0.01 in all cases. When analysing by hyperglycaemic status, FPG, PG and HbA1c were positively associated with CAVI and baPWV in subjects with type 2 diabetes mellitus.

Conclusion

FPG, PG and HbA1c show a positive association with CAVI and baPWV, in Caucasian adults with intermediate cardiovascular risk factors. When analysing by hyperglycaemic status, the association is only maintained in subjects with type 2 diabetes mellitus.

Trial registration

Clinical Trials.gov Identifier: NCT01428934. Registered 2 September 2011. Retrospectively registered. Last updated September 8, 2016.



Autor: Leticia Gomez-Sanchez , Luis Garcia-Ortiz, Maria C. Patino-Alonso, Jose I. Recio-Rodriguez, Natalia Feuerbach, Ruth Marti, Cristi

Fuente: http://plos.srce.hr/



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