Vibrotactile stimulation: A non-pharmacological intervention for opioid-exposed newbornsReportar como inadecuado

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To examine the therapeutic potential of stochastic vibrotactile stimulation SVS as a complementary non-pharmacological intervention for withdrawal in opioid-exposed newborns.

Study design

A prospective, within-subjects single-center study was conducted in 26 opioid-exposed newborns >37 weeks; 16 male hospitalized since birth and treated pharmacologically for Neonatal Abstinence Syndrome. A specially-constructed mattress delivered low-level SVS 30-60Hz, 10–12μm RMS, alternated in 30-min intervals between continuous vibration ON and no vibration OFF over a 6–8 hr session. Movement activity, heart rate, respiratory rate, axillary temperature and blood-oxygen saturation were calculated separately for ON and OFF.


There was a 35% reduction in movement activity with SVS p<0.001, with significantly fewer movement periods >30 sec duration for ON than OFF p = 0.003. Incidents of tachypneic breaths and tachycardic heart beats were each significantly reduced with SVS, whereas incidents of eupneic breaths and eucardic heart beats each significantly increased with SVS p<0.03. Infants maintained body temperature and arterial-blood oxygen level independent of stimulation condition.


SVS reduced hyperirritability and pathophysiological instabilities commonly observed in pharmacologically-managed opioid-exposed newborns. SVS may provide an effective complementary therapeutic intervention for improving autonomic function in newborns with Neonatal Abstinence Syndrome.

Autor: Ian Zuzarte, Premananda Indic, Bruce Barton, David Paydarfar, Francis Bednarek †, Elisabeth Bloch-Salisbury



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