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Background

Novelty-seeking NS and impulsive personality traits have been proposed to reflect an interplay between fronto-cortical and limbic systems, including the limbic striatum LS. Although neuroimaging studies have provided some evidence for this, most are comprised of small samples and many report surprisingly large effects given the challenges of trying to relate a snapshot of brain function or structure to an entity as complex as personality. The current work tested a priori hypotheses about associations between striatal dopamine DA release, cortical thickness CT, and NS in a large sample of healthy adults.

Methods

Fifty-two healthy adults 45M-7F; age: 23.8±4.93 underwent two positron emission tomography scans with 11Craclopride specific for striatal DA D2-3 receptors with or without amphetamine 0.3 mg-kg, p.o

Structural magnetic resonance image scans were acquired, as were Tridimensional Personality Questionnaire data. Amphetamine-induced changes in 11Craclopride binding potential values ΔBPND were examined in the limbic, sensorimotor SMS and associative AST striatum. CT measures, adjusted for whole brain volume, were extracted from the dorsolateral sensorimotor and ventromedial-limbic cortices.

Results

BPND values were lower in the amphetamine vs. no-drug sessions, with the largest effect in the LS. When comparing low vs. high LS ΔBPND groups median split, higher NS2 impulsiveness scores were found in the high ΔBPND group. Partial correlations age and gender as covariates yielded a negative relation between ASTS ΔBPND and sensorimotor CT; trends for inverse associations existed between ΔBPND values in other striatal regions and frontal CT. In other words, the greater the amphetamine-induced striatal DA response, the thinner the frontal cortex.

Conclusions

These data expand upon previously reported associations between striatal DA release in the LS and both NS related impulsiveness and CT in the largest sample reported to date. The findings add to the plausibility of these associations while suggesting that the effects are likely weaker than has been previously proposed.



Autor: Natalia Jaworska, Sylvia M. Cox, Kevin F. Casey, Isabelle Boileau, Mariya Cherkasova, Kevin Larcher, Alain Dagher, Chawki Benkelf

Fuente: http://plos.srce.hr/



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