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International Journal of NephrologyVolume 2012 2012, Article ID 940320, 5 pages

Clinical Study

Division of Nephrology, University of Rochester Medical Center, 601 Elmwood Avenue, P.O. Box 675, Rochester, NY 14642, USA

Division of Oncology, Dalhousie University, Room 457A, Bethune Building, 1276 South Park Street Halifax, Nova Scotia, Canada B3H 2Y9

Department of Pharmacy, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA

Departments of Public Health and Preventive Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA

Department of Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA

Received 3 November 2012; Revised 13 December 2012; Accepted 17 December 2012

Academic Editor: Greg Tesch

Copyright © 2012 Shaifali Sandal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The use of sodium polystyrene sulfonate in decreasing serum potassium has recently been questioned due to the lack of documented effectiveness. Methods. A retrospective cohort analysis of all hospitalized patients who received sodium polystyrene sulfonate over four months was performed. The change in serum potassium was noted over a period of 24 hours. Patients who received any other form of potassium-altering drug or treatment were excluded. Results. The administration of sodium polystyrene sulfonate reduced serum potassium by 16.7% as compared to the baseline serum potassium over a period of 24 hours. During this same time, no change in serum creatinine was identified . In addition, there was no correlation between potassium and creatinine change r

= 0.0004 and . Patients with higher initial serum potassium ≥5.6 mEq-L reduced their potassium concentration 4% more than those with initial serum potassium of <5.6 mEq-L; however, this reduction did not reach statistical significance . There was no significant difference in the effectiveness of 15 gm and 30 gm resin preparation . Thirteen deaths were noted in our cohort, of which one death was due to ischemic colitis. Conclusion. We conclude that sodium polystyrene sulfonate is effective in lowering serum potassium.





Autor: Shaifali Sandal, Hatim Karachiwala, John Noviasky, Dongliang Wang, William C. Elliott, and David F. Lehmann

Fuente: https://www.hindawi.com/



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