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Mediators of Inflammation - Volume 13 2004, Issue 2, Pages 111-117

Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, Russia



Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

BACKGROUND and aim: Macrolide antibiotics are widely used in the treatment of suppurative lung diseases including cystic fibrosis CF, the most common inherited fatal disease in the Caucasian population. This condition is characterized by secondary Pseudomonas infection resulting in neutrophil infiltration within the airways. The aim of the study was to investigate the evolution of inflammatory process in CF patients receiving long-term clarithromycin therapy.

Methods: Twenty-seven CF patients mean age, 12 years were enrolled into the study. Beside the basic therapy the patients were treated with clarithromycin at a dose of 250 mg every other day orally. All patients were routinely examined every 3 months. Blood and sputum were collected before clarithromycin treatment and then again 3, 6 and 12 months after the drug prescription. Cytokine concentrations tumor necrosis factor-α, interleukin-8, interleukin-4, interferon-γ in the sputum and plasma were assayed. Peripheral blood lymphocyte response to phytohemagglutinin was also evaluated.

Results: Clarithromycin treatment resulted in a marked reduction of the cytokine levels both in the sputum and plasma specimens. At the same time, the interferon-γ-interleukin-4 ratio has been significantly elevated. In addition, a sustained increase of peripheral blood lymphocyte response to phytohemagglutinin was demonstrated. These changes were associated with a significant improvement of the lung function.

Conclusions: The beneficial effect of the prolonged treatment of CF patients with a 14-membered ring macrolide antibiotic clarithromycin seems to be associated not only with down-regulation of the inflammatory response, but also with immunological changes including the switch from Th2 to Th1 type response.





Autor: Alexander L. Pukhalsky, Galina V. Shmarina, Nikolai I. Kapranov, Svetlana N. Kokarovtseva, Daria Pukhalskaya, and Natalia J. Kash

Fuente: https://www.hindawi.com/



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