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Mediators of Inflammation - Volume 2 1993, Issue 5, Pages 367-371

Research paper

Virology Unit, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 653, Beer Sheva 84105, Israel

Medizinische Hochschule Hannover, Abteilung Rheumatologie, Postfach 610180, Hannover 61 D-3000, Germany

Received 30 June 1993; Accepted 22 July 1993

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this study levels of prostaglandin E2 PGE2, tumour necrosis factor TNF and interleukin-1 IL-1 alpha in medium from monocyte derived macrophages MdM infected with Chlamydia trachomatis L2-434-Bu or K biovars. TNF and PGE2 were found in both cases while IL-1 alpha was not detected. Both TNF and PGE2 levels were higher in the medium of the MdM infected with K biovars. TNF reached maximum levels 24 h postinfection, and then declined, while PGE2 levels increased continuously during the infection time up to 96 h post-infection. Addition of dexamethasone inhibited production of TNF and PGE2. Inhibition of PGE2 production by indomethacin resulted in increased production of TNF, while addition of PGE2 caused partial inhibition of TNF production from infected MdM.





Autor: E. Manor, E. Schmitz, and I. Sarov

Fuente: https://www.hindawi.com/



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