Survival of Mexican Children with Acute Myeloid Leukaemia Who Received Early Intensification Chemotherapy and an Autologous TransplantReportar como inadecuado




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BioMed Research International - Volume 2015 2015, Article ID 940278, 10 pages -

Research Article

Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad UMAE, Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social IMSS, Avenida Jacarandas Esquina Vallejo, S-N, Colonia La Raza, 02990 México, DF, Mexico

Laboratorio de Investigación, Hospital Infantil de México “Federico Gómez”, Secretaría de Salud, Calle Doctor Marquez 162, Colonia Doctores, Delegación Cuauhtémoc, 06720 México, DF, Mexico

Hospital de Oncología, Centro Médico Nacional “Siglo XXI”, IMSS, Avenida Cuauhtemoc 330, 06720 México, DF, Mexico

Unidad de Investigación en Inmunología, Unidad Médica de Alta Especialidad UMAE, Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social IMSS, Avenida Jacarandas Esquina Vallejo, S-N, Colonia La Raza, 02990 México, DF, Mexico

Hematología Pediátrica, Centro Médico Nacional “Siglo XXI”, IMSS, Avenida Cuauhtemoc 330, 06720 México, DF, Mexico

Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, 04510 México, DF, Mexico

Unidad de Investigación en Epidemiología Clínica, UMAE Hospital de Pediatría, Centro Médico Nacional “Siglo XXI”, IMSS, Avenida Cuauhtemoc 330, 4to Piso Edificio de la Academia Nacional de Medicina, 06720 México, DF, Mexico

Received 30 June 2014; Revised 23 October 2014; Accepted 2 November 2014

Academic Editor: Richard J. Q. McNally

Copyright © 2015 Elva Jiménez-Hernández et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologous transplant, either underwent early intensified chemotherapy or did not undergo such treatment. Procedure. This was a cohort study with a historical control group, forty patients, less than 16 years old. Group A 20 patients, diagnosed in the period 2005–2007, was treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy: high doses of cytarabine and mitoxantrone. Group B 20 patients, diagnosed in the period 1999–2004, was treated as Group A, but without the early intensified chemotherapy. Results. Relapse-free survival for Group A was 90% whereas that for Group B it was 60% . Overall survival for Group A 18, 90% was higher than that for Group B 60%. Complete remission continued for two years of follow-up. Conclusions. Relapse-free survival for paediatric patients treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy was higher than that for those who did not receive early intensified chemotherapy.





Autor: Elva Jiménez-Hernández, María Teresa Dueñas-González, José Arellano-Galindo, María Elena Medrano-Ortíz-De-Zárate, Vil

Fuente: https://www.hindawi.com/



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