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Evidence-Based Complementary and Alternative Medicine - Volume 2017 2017, Article ID 9402615, 7 pages - https:-doi.org-10.1155-2017-9402615

Research Article

Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Department of Endocrinology, Yancheng Third Hospital, The Affiliated Hospital of Southeast University Medical College, Yancheng, China

Department of Neurosurgery, Yancheng City No. 1 People’s Hospital, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng, China

Correspondence should be addressed to Jianbo Li

Received 14 November 2016; Revised 6 January 2017; Accepted 16 January 2017; Published 8 February 2017

Academic Editor: Michael Silbermann

Copyright © 2017 Shu Ruan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Thyroid cancer is one of the most common types of cancer in endocrine system. In latest studies, harmine has been proved to inhibit the growth of several cancers in vitro and in vivo. In the current study, we evaluated the in vitro and in vivo anticancer efficiency of harmine against thyroid cancer cell line TPC-1. The in vitro cytotoxicity of harmine evaluated by XTT assay indicated that harmine suppressed the proliferation of TPC-1 cells in a dose- and time-dependent manner. Moreover, harmine dose-dependently induced apoptosis of TPC-1 cells through regulating the ratio of Bcl-2-Bax. The colony forming ability of TPC-1 cells was also time-dependently inhibited by harmine. The inhibitory effects of harmine on migration and invasion of TPC-1 cells were studied by wound scratching and Transwell assays. In vivo evaluation showed that harmine effectively inhibited the growth of thyroid cancer in a dose-dependent manner in nude mice. Therefore, harmine might be a promising herbal medicine in the therapy of thyroid cancer and further efforts are needed to explore this therapeutic strategy.





Autor: Shu Ruan, Feng Jia, and Jianbo Li

Fuente: https://www.hindawi.com/



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