Neuroendocrine carcinoma of the esophagus: Clinicopathological and immunohistochemical features of 14 casesReportar como inadecuado

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Neuroendocrine carcinoma NEC of the esophagus is a rare and highly aggressive disease but the biological features are poorly understood. The objective of this study was to analyze the clinicopathological and immunohistochemical features of NEC of the esophagus.


Fourteen patients diagnosed with NEC of the esophagus from 1998 to 2013 were included in this study. Clinicopathologic features, therapeutic outcomes and immunohistochemical results were analyzed.


Eleven out of 14 cases showed protruding or localized type with or without ulceration. Only three patients were negative for both lymph node and organ metastasis and seven cases were positive for metastases to distant organs and-or distant lymph nodes. Of the six patients with limited disease LD, three patients were treated by surgery. Three patients with LD and seven patients with extensive disease ED were initially treated with chemotherapy, except for one who underwent concurrent chemo-radiotherapy due to passage disturbance. The median survival of patients with LD was 8.5 months, whereas that of patients with LD was 17 months. Among the 14 cases, 12 cases 83.3%, 13 cases 91.7% and 12 cases 83.3% showed positive immunostaining for choromogranin A, synaptophysin and CD56, respectively. Nine of 14 cases 64.2% presented positive staining for c-kit and most 8-9, 88% simultaneously showed p53 protein abnormality. Two cases were negative for c-kit and p53, and positive for CK20.


Consistent with previous reports, the prognosis of NEC of esophagus is dismal. From the results of immunohistochemical study, NEC of esophagus might be divided into two categories due to the staining positivity of c-kit and p53. This study provides new insight into the biology of NEC of the esophagus.

Autor: Akinori Egashira , Masaru Morita, Reiko Kumagai, Ken-ichi Taguchi, Masanobu Ueda, Shohei Yamaguchi, Manabu Yamamoto, Kazuhito Min



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