Polymorphisms associated with a tropical climate and root crop diet induce susceptibility to metabolic and cardiovascular diseases in Solomon IslandsReport as inadecuate




Polymorphisms associated with a tropical climate and root crop diet induce susceptibility to metabolic and cardiovascular diseases in Solomon Islands - Download this document for free, or read online. Document in PDF available to download.

The people of the Solomon Islands represent an Austronesian AN-speaking population’s adaptation to a humid tropical environment and subsistence of tuberous crops. Genome-wide association studies GWASs of other populations e.g. the Human Genome Diversity Project HGDP have suggested the existence of genotypes adaptive to ecoregion, diet, and subsistence, and that those genotypes are also associated with metabolic and cardiovascular diseases. Recently, the incidence of non-communicable diseases has been increasing in the Solomon Islands. In the present study, we explored the association of genotypes adaptive to a tropical environment and tuberous crop diet with metabolic and cardiovascular conditions in rural and urban AN-speaking Melanesian and Micronesian populations of the Solomon Islands. A total of 561 participants were genotyped for single nucleotide polymorphisms SNPs potentially associated with a tropical environment rs174570 and rs2237892 and a tuberous crop diet rs162036, rs185819, and rs2722425. The results showed that the allele frequencies of the Solomon Islands populations adopted patterns similar to those in populations from other hot, tropical areas with a tuberous crop diet in previous studies. Furthermore, rs162036, rs185819, rs2237892, and rs2722425 were all strongly associated with one or more metabolic and cardiovascular conditions. The derived allele of rs2722425 i.e. rs2722425-G was significantly associated with an elevated LDL level P = 0.000264 even after the significance level was adjusted for multiple testing i.e., α = 0.0005. Our results suggest that the inhabitants of the Solomon Islands exhibit the effects of the tropical environment and tuberous crop diet on their allele frequencies, and that their susceptibility to metabolic and cardiovascular diseases is therefore considered to be associated with their environment and diet.



Author: Takuro Furusawa , Izumi Naka, Taro Yamauchi, Kazumi Natsuhara, Ricky Eddie, Ryosuke Kimura, Minato Nakazawa, Takafumi Ishida, Ryu

Source: http://plos.srce.hr/



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