Evaluation of 18-F-fluoro-2-deoxyglucose FDG positron emission tomography-computed tomography PET-CT as a staging and monitoring tool for dogs with stage-2 splenic hemangiosarcoma – A pilot studyReport as inadecuate




Evaluation of 18-F-fluoro-2-deoxyglucose FDG positron emission tomography-computed tomography PET-CT as a staging and monitoring tool for dogs with stage-2 splenic hemangiosarcoma – A pilot study - Download this document for free, or read online. Document in PDF available to download.

Positron Emission Tomography-Computed Tomography PET-CT is routinely used for staging and monitoring of human cancer patients and is becoming increasingly available in veterinary medicine. In this study, 18-fluorodeoxyglucose 18FDG-PET-CT was used in dogs with naturally occurring splenic hemangiosarcoma HSA to assess its utility as a staging and monitoring modality as compared to standard radiography and ultrasonography. Nine dogs with stage-2 HSA underwent 18FDG-PET-CT following splenectomy and prior to commencement of chemotherapy. Routine staging thoracic radiography and abdominal ultrasonography was performed prior to 18FDG-PET-CT in all dogs. When abnormalities not identified on routine tests were noted on 18FDG-PET-CT, owners were given the option to repeat a PET-CT following treatment with eBAT. A PET-CT scan was repeated on Day 21 in three dogs. Abnormalities not observed on conventional staging tools, and most consistent with malignant disease based on location, appearance, and outcome, were detected in two dogs and included a right atrial mass and a hepatic nodule, respectively. These lesions were larger and had higher metabolic activity on the second scans. 18FDG-PET-CT has potential to provide important prognostic information and influence treatment recommendations for dogs with stage-2 HSA. Additional studies will be needed to precisely define the value of this imaging tool for staging and therapy monitoring in dogs with this and other cancers.



Author: Antonella Borgatti , Amber L. Winter, Kathleen Stuebner, Ruth Scott, Christopher P. Ober, Kari L. Anderson, Daniel A. Feeney, Dan

Source: http://plos.srce.hr/



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