Clinically determined type of 18F-fluoro-2-deoxyglucose uptake as an alternative prognostic marker in resectable pancreatic cancerReport as inadecuate




Clinically determined type of 18F-fluoro-2-deoxyglucose uptake as an alternative prognostic marker in resectable pancreatic cancer - Download this document for free, or read online. Document in PDF available to download.

Purpose

To investigate the association between clinical PET positron emission tomography type and oncologic outcome in resectable pancreatic cancer.

Methods

Between January 2008 and October 2012, patients who underwent potentially curative resection for resectable pancreatic ductal adenocarcinoma without neoadjuvant treatment were retrospectively investigated. Clinical PET type was defined as follows: pancreatic cancer with similar 18FDG uptake to renal calyx was determined as kidney-type K-type, and relatively lower 18FDG uptake than that of renal calyx was regarded as Non-K type.

Results

A total of 53 patients were enrolled. After agreement-based reclassification, agreement based K-type aK-type was noted in 34 patients 64.2%, and agreement based Non-K type aNon K-type was found in 19 patients 35.8%. There was a significant difference between aK-type and aNon K-type pancreatic cancer tumor size P = 0.030, adjusted CA 19–9 P = 0.007, maximum standard uptake value SUVmax,P<0.001, metabolic tumor volume MTV2.5, P<0.001, total lesion glycolysis TLG, P<0.001. K-type pancreatic cancer n = 31 showed a significantly shorter disease-free time compared with Non-K type n = 16 10.8 vs. 24.1 months, P = 0.013. It was also noted that aK-type showed inferior disease-free survival to that of aNon-K type pancreatic cancer 11.9 vs. 28.6 months, P = 0.012.

Conclusions

Clinical PET type is a reliable clinical marker to estimate aggressive tumor biology and can be utilized in predicting tumor recurrence and necessity for postoperative chemotherapy.



Author: Jae Uk Chong, Ho Kyoung Hwang, Jin Ho Lee, Mijin Yun, Chang Moo Kang , Woo Jung Lee

Source: http://plos.srce.hr/



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