Prevalence and associated comorbidities of restless legs syndrome RLS: Data from a large population-based door-to-door survey on 19176 adults in Tehran, IranReport as inadecuate




Prevalence and associated comorbidities of restless legs syndrome RLS: Data from a large population-based door-to-door survey on 19176 adults in Tehran, Iran - Download this document for free, or read online. Document in PDF available to download.

Background

Discrepancies have been reported in the prevalence rate of restless legs syndrome RLS among different ethnic groups and geographic populations. Furthermore, there are disagreements on determinant factors and associated comorbidities of RLS. We aimed to estimate prevalence of RLS and investigate its associated comorbid conditions and risk factors in a large population-based door-to-door survey.

Methods

Following a multistage random sampling from the households lived in 22 urban districts of Tehran, Iran, 19176 participants with ≥30 years of age were recruited. Trained surveyors filled study checklist consisting of baseline characteristics, risk factors and comorbidity profile and the International RLS Study Group IRLSSG diagnostic criteria through face-to-face interviews.

Results

In total, 1580 individuals were positively screened for RLS resulting in a standardized prevalence rate of 60.0-1000. There was a gradual increase in RLS prevalence by advancing age, however, sex difference disappeared after adjustment. Parkinsonism adjusted odds’ ratio adj-OR = 7.4 95% CI: 5.3–10.4, peripheral neuropathy adj-OR = 3.7 95% CI: 3.3–4.1, subjective cognitive impairment SCI adj-OR = 3.1 95% CI: 2.7–3.4, acting out dreams adj-OR = 2.8 95% CI: 2.5–3.2, hyposmia adj-OR = 2.5 95% CI: 2.2–2.9, active smoking adj-OR = 1.5 95% CI: 1.3–1.9 and additional number of cardiometabolic diseases associated with higher risk of RLS adj-OR = 1.6 95% CI: 1.2–2.3.

Conclusion

Our findings showed that neuro-cognitive co-morbidities such as parkinsonism, peripheral neuropathy, SCI, acting out dreams and hyposmia as well as cardio-metabolic risk factors and diseases were independent determinants of RLS. It is recommended to screen individuals with either these comorbid conditions for RLS or the ones with RLS for the accompanying diseases.



Author: Seyed-Mohammad Fereshtehnejad , Arash Rahmani, Mahdiyeh Shafieesabet, Mahshid Soori, Ahmad Delbari, Mohammad Reza Motamed, Johan

Source: http://plos.srce.hr/



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