The reporting of study and population characteristics in degenerative cervical myelopathy: A systematic reviewReport as inadecuate




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Object

Degenerative cervical myelopathy DCM is a disabling and increasingly prevalent condition. Variable reporting in interventional trials of study design and sample characteristics limits the interpretation of pooled outcomes. This is pertinent in DCM where baseline characteristics are known to influence outcome. The present study aims to assess the reporting of the study design and baseline characteristics in DCM as the premise for the development of a standardised reporting set.

Methods

A systematic review of MEDLINE and EMBASE databases, registered with PROSPERO CRD42015025497 was conducted in accordance with PRISMA guidelines. Full text articles in English, with >50 patients prospective or >200 patients retrospective, reporting outcomes of DCM were deemed to be eligible.

Results

A total of 108 studies involving 23,876 patients, conducted world-wide, were identified. 33 31% specified a clear primary objective. Study populations often included radiculopathy 51, 47% but excluded patients who had undergone previous surgery 42, 39%. Diagnositic criteria for myelopathy were often uncertain; MRI assessment was specified in only 67 62% of studies. Patient comorbidities were referenced by 37 34% studies. Symptom duration was reported by 46 43% studies. Multivariate analysis was used to control for baseline characteristics in 33 31% of studies.

Conclusions

The reporting of study design and sample characteristics is variable. The development of a consensus minimum dataset for CODE-DCM will facilitate future research synthesis in the future.



Author: Benjamin M. Davies, M. McHugh, A. Elgheriani, Angelos G. Kolias, Lindsay Tetreault, Peter J. A. Hutchinson, Michael G. Fehlings,

Source: http://plos.srce.hr/



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